Complex Inheritance for Susceptibility to Sudden Cardiac Death

Title:Complex Inheritance for Susceptibility to Sudden Cardiac Death

Volume: 19 Issue: 39

Author(s): Raha Pazoki, Michael W.T. Tanck, Arthur A.M. Wilde and Connie R. Bezzina

Affiliation:

• Department of Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center Amsterdam (AMC), PO Box 22660, 1100 DD Amsterdam, The Netherlands,Netherlands

Keywords: Ventricular arrhythmia, genome-wide association studies, sudden cardiac death, genetics.

Abstract: Sudden cardiac death (SCD) from ventricular fibrillation during myocardial infarction is a leading cause of total and cardiovascular mortality. It has a multifactorial, complex nature and aggregates in families, implicating the involvement of heritable factors in the determination of risk. During the last few years, genome-wide association studies have uncovered common genetic variants modulating risk of SCD. We here review the current insight on genetic determinants of SCD in the community and describe the genome-wide association approaches undertaken thus far in uncovering genetic determinants of SCD risk.

Cite this article as:

Pazoki Raha, Tanck W.T. Michael, Wilde A.M. Arthur and Bezzina R. Connie, Complex Inheritance for Susceptibility to Sudden Cardiac Death, Current Pharmaceutical Design 2013; 19(39) . https://dx.doi.org/10.2174/138161281939131127112906