Abstract
As a part of our ongoing studies in developing new derivatives as dual antibacterial/antifungal agents, we describe the synthesis of novel amino substituted benzofuroxan derivatives. These compounds were tested for their antifungal activity against various strains. It is shown that their antimicrobial and antifungal activities depend on the structure of the amino moiety, on the position and on the nature of the substituents of the benzofuroxan ring. They displayed good bacteriostatic and fungistatic activities comparable to those of reference drugs. The more active benzofuroxan derivatives have been studied intraperitoneally in mice to get a first estimation of their toxicity. Preliminary results have also shown that some derivatives are able to inhibit enzymes such as GDH (glucose dehydrogenase).
Keywords: Bacteriostatic activity, Fungistatic activity, Intraperitoneal introduction, Amine substitution, Benzofuroxan.
Letters in Drug Design & Discovery
Title:The Study of the Biological Activity of Amino-Substituted Benzofuroxans
Volume: 11 Issue: 4
Author(s): Elena A. Chugunova, Alexandra D. Voloshina, Rezeda E. Mukhamatdinova, Igor V. Serkov, Alexey N. Proshin, Elmira M. Gibadullina, Alexander R. Burilov, Natalia V. Kulik, Vladimir V. Zobov, Dmitry B. Krivolapov, Alexey B. Dobrynin and Regis Goumont
Affiliation:
Keywords: Bacteriostatic activity, Fungistatic activity, Intraperitoneal introduction, Amine substitution, Benzofuroxan.
Abstract: As a part of our ongoing studies in developing new derivatives as dual antibacterial/antifungal agents, we describe the synthesis of novel amino substituted benzofuroxan derivatives. These compounds were tested for their antifungal activity against various strains. It is shown that their antimicrobial and antifungal activities depend on the structure of the amino moiety, on the position and on the nature of the substituents of the benzofuroxan ring. They displayed good bacteriostatic and fungistatic activities comparable to those of reference drugs. The more active benzofuroxan derivatives have been studied intraperitoneally in mice to get a first estimation of their toxicity. Preliminary results have also shown that some derivatives are able to inhibit enzymes such as GDH (glucose dehydrogenase).
Export Options
About this article
Cite this article as:
Chugunova A. Elena, Voloshina D. Alexandra, Mukhamatdinova E. Rezeda, Serkov V. Igor, Proshin N. Alexey, Gibadullina M. Elmira, Burilov R. Alexander, Kulik V. Natalia, Zobov V. Vladimir, Krivolapov B. Dmitry, Dobrynin B. Alexey and Goumont Regis, The Study of the Biological Activity of Amino-Substituted Benzofuroxans, Letters in Drug Design & Discovery 2014; 11 (4) . https://dx.doi.org/10.2174/1570180810666131122010403
DOI https://dx.doi.org/10.2174/1570180810666131122010403 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
The Orvinols and Related Opioids - High Affinity Ligands with Diverse Efficacy Profiles
Current Pharmaceutical Design Novel Therapeutic Targets for Prevention and Therapy of Sepsis Associated Acute Kidney Injury
Current Drug Targets Ventilation During Pediatric CPR
Current Pediatric Reviews Benzenecarboxamide Analogs of Fluoroquinolones (BCFQs). Antibacterial Activity and SAR Studies
Letters in Drug Design & Discovery Study of the cis-trans Isomerization of the Amino-Acyl prolyl Peptide Bond. Application to the Design of Novel Inhibitors of Immunophilins
Current Organic Chemistry In Silico Modeling of P450 Substrates, Inhibitors, Activators, and Inducers
Combinatorial Chemistry & High Throughput Screening Efficacy and Safety of Corticosteroids’ Administration for Pulmonary Immaturity in Anticipated Preterm Delivery
Current Pharmaceutical Design Clinical Value of COVID-19 Chest Radiography and High-Resolution CT Examination
Current Medical Imaging p38 MAP Kinase Inhibitors as Anti inflammatory Agents
Mini-Reviews in Medicinal Chemistry Advances in Drug Discovery and Development for Pediatric Tuberculosis
Mini-Reviews in Medicinal Chemistry Orphan Nuclear Receptor Modulators
Current Topics in Medicinal Chemistry New Insights into the Roles of NAD+-Poly(ADP-ribose) Metabolism and Poly(ADP-ribose) Glycohydrolase
Current Protein & Peptide Science Evaluation and Prediction of End of Second-wave and Starting of Thirdwave Covid-19 Cases in India
Current Signal Transduction Therapy Roles of Secreted Phospholipases A<sub>2</sub> in the Mammalian Immune System
Protein & Peptide Letters Interest of Antioxidant Agents in Parasitic Diseases. The Case Study of Coumarins
Current Topics in Medicinal Chemistry Metabolic and Amino Acid Alterations of the Tumor Microenvironment
Current Medicinal Chemistry The Medicinal Chemistry of Structure-based Inhibitor/Drug Design: Current Progress and Future Prospective
Current Topics in Medicinal Chemistry Comparison of General Dietary and Lifestyle Habits Before and During COVID-19 among the Saudi Adult Population in Riyadh
Current Nutrition & Food Science Filling the Pipeline - New Drugs for an Old Disease
Current Topics in Medicinal Chemistry CCR2 Antagonists
Current Topics in Medicinal Chemistry