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Current Neuropharmacology


ISSN (Print): 1570-159X
ISSN (Online): 1875-6190

Tissue Injury and Related Mediators of Pain Exacerbation

Author(s): Fumimasa Amaya, Yuta Izumi, Megumi Matsuda and Mika Sasaki

Volume 11 , Issue 6 , 2013

Page: [592 - 597] Pages: 6

DOI: 10.2174/1570159X11311060003

Price: $65


Tissue injury and inflammation result in release of various mediators that promote ongoing pain or pain hypersensitivity against mechanical, thermal and chemical stimuli. Pro-nociceptive mediators activate primary afferent neurons directly or indirectly to enhance nociceptive signal transmission to the central nervous system. Excitation of primary afferents by peripherally originating mediators, so-called “peripheral sensitization”, is a hallmark of tissue injuryrelated pain. Many kinds of pro-nociceptive mediators, including ATP, glutamate, kinins, cytokines and tropic factors, synthesized at the damaged tissue, contribute to the development of peripheral sensitization. In the present review we will discuss the molecular mechanisms of peripheral sensitization following tissue injury.

Keywords: Peripheral sensitization, postoperative pain, primary afferent neuron.

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