Abstract
Treatment of intoxications caused by nerve agents and organophosphorus pesticides consists of different approaches. The first approach is called prophylaxis or pre-exposure administration of antidotes such as cholinesterase reactivators or bioscavengers. The second, post-exposure treatment consists of anticholinergic drugs, acetylcholinesterase reactivators and anticonvulsants. This article is aimed at both mentioned approaches, especially focused on cholinesterase reactivators, which are a broad group of structurally different compounds that can be used in prophylaxis (separately or in combination with butyrylcholinesterase) and also as post-exposure treatment.
Keywords: Acetylcholinesterase, butyrylcholinesterase, nerve agents, pesticides, poisoning, prophylaxis, treatment, antidote, organophosphate, reactivator, protection, oxime, toxicity.
Mini-Reviews in Medicinal Chemistry
Title:Prophylaxis and Post-exposure Treatment of Intoxications Caused by Nerve Agents and Organophosphorus Pesticides
Volume: 13 Issue: 14
Author(s): Kamil Kuca, Daniel Jun, Kamil Musilek, Miroslav Pohanka, Jana Zdarova Karasova and Ondrej Soukup
Affiliation:
Keywords: Acetylcholinesterase, butyrylcholinesterase, nerve agents, pesticides, poisoning, prophylaxis, treatment, antidote, organophosphate, reactivator, protection, oxime, toxicity.
Abstract: Treatment of intoxications caused by nerve agents and organophosphorus pesticides consists of different approaches. The first approach is called prophylaxis or pre-exposure administration of antidotes such as cholinesterase reactivators or bioscavengers. The second, post-exposure treatment consists of anticholinergic drugs, acetylcholinesterase reactivators and anticonvulsants. This article is aimed at both mentioned approaches, especially focused on cholinesterase reactivators, which are a broad group of structurally different compounds that can be used in prophylaxis (separately or in combination with butyrylcholinesterase) and also as post-exposure treatment.
Export Options
About this article
Cite this article as:
Kuca Kamil, Jun Daniel, Musilek Kamil, Pohanka Miroslav, Karasova Zdarova Jana and Soukup Ondrej, Prophylaxis and Post-exposure Treatment of Intoxications Caused by Nerve Agents and Organophosphorus Pesticides, Mini-Reviews in Medicinal Chemistry 2013; 13 (14) . https://dx.doi.org/10.2174/13895575113136660108
DOI https://dx.doi.org/10.2174/13895575113136660108 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
Call for Papers in Thematic Issues
Bioprospecting of Natural Products as Sources of New Multitarget Therapies
According to the Convention on Biological Diversity, bioprospecting is the exploration of biodiversity and indigenous knowledge to develop commercially valuable products for pharmaceutical and other applications. Bioprospecting involves searching for useful organic compounds in plants, fungi, marine organisms, and microorganisms. Natural products traditionally constituted the primary source of more than ...read more
Computational Frontiers in Medicinal Chemistry
The thematic issue "Computational Frontiers in Medicinal Chemistry" provides a robust platform for delving into state-of-the-art computational methodologies and technologies that significantly propel advancements in medicinal chemistry. This edition seeks to amalgamate top-tier reviews spotlighting the latest trends and breakthroughs in the fusion of computational approaches, including artificial intelligence (AI) ...read more
Mitochondria as a Therapeutic Target in Metabolic Disorders
Mitochondria are the primary site of adenosine triphosphate (ATP) production in mammalian cells. Moreover, these organelles are an important source of reactive oxygen and nitrogen species in virtually any nucleated cell type. The modulation of a myriad of cellular signaling pathways depends on the mitochondrial physiology. Mitochondrial dysfunction is observed ...read more
Natural Products and Dietary Supplements in Alleviation of Metabolic, Cardiovascular, and Neurological Disorders
Metabolic disorders like diabetes, obesity, inflammation, oxidative stress, cancer etc, cardiovascular disorders like angina, myocardial infarction, congestive heart failure etc as well as neurological disorders like Alzheimer?s, Parkinson?s, Epilepsy, Depression, etc are the global burden. They covered the major segment of the diseases and disorders from which the human community ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Perspectives in Nanomedicine-Based Research Towards Cancer Therapies
Current Nanoscience Therapeutic Targets in Extracellular Protein Deposition Diseases
Current Medicinal Chemistry Targeting Nitrosative Stress for Neurovascular Protection: New Implications in Brain Diseases
Current Drug Targets Perspectives on Medicinal Properties of Mangiferin
Mini-Reviews in Medicinal Chemistry Nitric Oxide: Target for Therapeutic Strategies in Alzheimers Disease
Current Pharmaceutical Design Endogenous Retroelements in Cellular Senescence and Related Pathogenic Processes: Promising Drug Targets in Age-Related Diseases
Current Drug Targets Fluparoxan: A Comprehensive Review of its Discovery, Adrenergic and CNS Activity and Treatment of Cognitive Dysfunction in Central Neurodegenerative Diseases
Mini-Reviews in Medicinal Chemistry S-Nitrosylation: Targets, Controls and Outcomes
Current Genomics The Association of Palmitoylethanolamide with Luteolin Decreases Neuroinflammation and Stimulates Autophagy in Parkinson's Disease Model
CNS & Neurological Disorders - Drug Targets Redox State, Oxidative Stress, and Molecular Mechanisms of Protective and Toxic Effects of Bilirubin on Cells
Current Pharmaceutical Design Hyperphosphorylation of Microtubule-Associated Protein Tau: A Promising Therapeutic Target for Alzheimer Disease
Current Medicinal Chemistry From Nature to Market: Examples of Natural Products that Became Drugs
Recent Patents on Biotechnology The Role of Nicotinamide Phosphoribosyltransferase in Cerebral Ischemia
Current Topics in Medicinal Chemistry Amyloid β-Peptide: The Inside Story
Current Alzheimer Research Physiological Functions of Presenilins; Beyond γ-Secretase
Current Pharmaceutical Biotechnology Nanomedicine and its Application in Treatment of Microglia-mediated Neuroinflammation
Current Medicinal Chemistry Neurotrophic Factors for the Investigation and Treatment of Movement Disorders
Current Medicinal Chemistry - Central Nervous System Agents Editorial [Hot Topic: Novel Therapeutic Strategies in Neural Diseases Uncover Unexpected Disease Connections: From Neurodegeneration and Addiction to Pain and Depression (Guest Editor: Gonzalo Herradon)]
Current Pharmaceutical Design Multifunctional Nanoparticles, Nanocages and Degradable Polymers as a Potential Novel Generation of Non-Invasive Molecular and Cellular Imaging Systems
Recent Patents on Nanotechnology Plant Polyphenols as Neuroprotective Agents in Parkinson’s Disease Targeting Oxidative Stress
Current Drug Targets