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Letters in Organic Chemistry


ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Synthesis, Spectroscopic and Structural Studies of New 2-Substituted 4- Nitroimidazoles

Author(s): Hayette Alliouche, Abdelmalek Bouraiou, Sofiane Bouacida, Mebarek Bahnous, Thierry Roisnel and Ali Belfaitah

Volume 11 , Issue 3 , 2014

Page: [174 - 179] Pages: 6

DOI: 10.2174/15701786113106660090

Price: $65


This study describes the synthesis of novel 4-nitro-2-substitutedimidazole derivatives via a transposition reaction of nitro group. Conversion of 5-nitro-2-phenylethanol (styryl) imidazole derivatives into the corresponding 4- nitroisomers was achieved in good yields in nitrobenzene using a catalytic amount of methyl iodide. Spectroscopic study and single crystal X-ray structures are reported for five compounds to understand the conformational structures of these compounds.

Keywords: Transposition reaction, 4-nitroimidazole, 5-nitroimidazole, crystal structure.

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