Abstract
The field of imaging science is growing immensely, with the emergence of “noninvasive” in vivo imaging technologies and imaging probes like Positron Emission Tomography (PET), Fluorescence Imaging (FI) and Magnetic Resonance Imaging (MRI), to observe events at molecular and cellular levels, and consequently to speed up drug development processes. For instance, the imaging of cancer specific molecular targets ought to permit precocious diagnosis and superior evaluation to oncology patients. Porphyrins and their derivatives (or related compounds, like phthalocyanines) represent one of the oldest, most widely studied chemical structures, both in nature and in biomedical applications. They display intrinsic affinity for tumor localization and their well-portrayed photophysical and photosensitizing properties can lead to their potential use as sensitizer in a variety of in vivo imaging technologies. This contribution will review recent developments involving tetrapyrrolic -based sensitizers for cancer detection, with emphasis on PET, FI and MRI technologies.
Keywords: Porphyrins, phthalocyanines, FI imaging, MRI imaging, PET imaging, theranostics.
Current Organic Synthesis
Title:Tetrapyrrolic Macrocycles: Potentialities in Medical Imaging Technologies
Volume: 11 Issue: 1
Author(s): Mário J.F. Calvete, Ana V.C. Simoes, César A. Henriques, Sara M.A. Pinto and Mariette M. Pereira
Affiliation:
Keywords: Porphyrins, phthalocyanines, FI imaging, MRI imaging, PET imaging, theranostics.
Abstract: The field of imaging science is growing immensely, with the emergence of “noninvasive” in vivo imaging technologies and imaging probes like Positron Emission Tomography (PET), Fluorescence Imaging (FI) and Magnetic Resonance Imaging (MRI), to observe events at molecular and cellular levels, and consequently to speed up drug development processes. For instance, the imaging of cancer specific molecular targets ought to permit precocious diagnosis and superior evaluation to oncology patients. Porphyrins and their derivatives (or related compounds, like phthalocyanines) represent one of the oldest, most widely studied chemical structures, both in nature and in biomedical applications. They display intrinsic affinity for tumor localization and their well-portrayed photophysical and photosensitizing properties can lead to their potential use as sensitizer in a variety of in vivo imaging technologies. This contribution will review recent developments involving tetrapyrrolic -based sensitizers for cancer detection, with emphasis on PET, FI and MRI technologies.
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Cite this article as:
Calvete J.F. Mário, Simoes V.C. Ana, Henriques A. César, Pinto M.A. Sara and Pereira M. Mariette, Tetrapyrrolic Macrocycles: Potentialities in Medical Imaging Technologies, Current Organic Synthesis 2014; 11 (1) . https://dx.doi.org/10.2174/15701794113106660090
DOI https://dx.doi.org/10.2174/15701794113106660090 |
Print ISSN 1570-1794 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6271 |
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Organic synthesis is a fundamental discipline in chemistry, crucial for the creation of complex molecules with diverse applications in pharmaceuticals, materials science, and beyond. However, the process of designing efficient synthetic routes for target molecules remains challenging. Chemical graph theory, a branch of theoretical chemistry, offers powerful tools for understanding ...read more
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