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Current Organocatalysis


ISSN (Print): 2213-3372
ISSN (Online): 2213-3380

Organocatalyzed Green Synthesis of 2,3-dihydropyrazines en Route to Medicinally Privileged Novel Polyheterocyclic Systems

Author(s): Debasish Bandyopadhyay, Artemio Zavala and Bimal K. Banik

Volume 1 , Issue 1 , 2014

Page: [59 - 65] Pages: 7

DOI: 10.2174/22133372114016660001


A straightforward green synthesis of 2,3-dihydropyrazines was accomplished under the catalytic influence of (±)-Camphor-10-sulfonic acid at room temperature by condensation of aliphatic 1,2-diamines with α,β-dicarbonyl compounds in aqueous medium. Remarkable aspects of this newly reported method are high yields, use of non-toxic solvents, mild conditions, simple workup and synthesis of complex molecules using an ecofriendly inexpensive organocatalyst. The present method is atom-economical, environmentally benign, and affords synthetically useful and challenging products very rapidly.

Keywords: Aqueous, anticancer, azaheterocycles, condensation, (±)-Camphor-10-sulfonic acid, 1, 2-Diamine, α, β-Dicarbonyl, dihydropyrazine, ecofriendly synthesis, heterocycles, green chemistry, organocatalyst, polyheterocyclic compounds, pyrazine, nitrogen heterocycles.

Graphical Abstract

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