Abstract
The arylation of 4-iodo-, 2-iodo- and 3-iodophenols with 2-fluorobenzaldehyde may be carried out in the presence of K2CO3 in DMF as the solvent under microwave conditions. The arylation of 4-iodophenole was promoted by the use of triethylbenzylammonium chloride (TEBAC) as the phase transfer catalyst. In the other model reactions, the use of TEBAC was harmful. By-products formed by isomerization and disproportionation were also detected.
Keywords: 2-Flourobenzaldehyde, Iodophenols, Arylation, Microwave, Phase transfer catalysis.
Letters in Drug Design & Discovery
Title:O-Arylation of Iodophenols with 2-Fluorobenzaldehyde Under Microwave Conditions
Volume: 11 Issue: 1
Author(s): Erika Bálint, Mónika Kállai, Orsolya Kovács, Hedvig Bölcskei and György Keglevich
Affiliation:
Keywords: 2-Flourobenzaldehyde, Iodophenols, Arylation, Microwave, Phase transfer catalysis.
Abstract: The arylation of 4-iodo-, 2-iodo- and 3-iodophenols with 2-fluorobenzaldehyde may be carried out in the presence of K2CO3 in DMF as the solvent under microwave conditions. The arylation of 4-iodophenole was promoted by the use of triethylbenzylammonium chloride (TEBAC) as the phase transfer catalyst. In the other model reactions, the use of TEBAC was harmful. By-products formed by isomerization and disproportionation were also detected.
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Cite this article as:
Bálint Erika, Kállai Mónika, Kovács Orsolya, Bölcskei Hedvig and Keglevich György, O-Arylation of Iodophenols with 2-Fluorobenzaldehyde Under Microwave Conditions, Letters in Drug Design & Discovery 2014; 11 (1) . https://dx.doi.org/10.2174/15701808113106660096
DOI https://dx.doi.org/10.2174/15701808113106660096 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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