Abstract
The regulation of endothelial NO synthase (eNOS) employs multiple different cellular control mechanisms impinging on level and activity of the enzyme. This review aims at summarizing the current knowledge on the posttranslational modifications of eNOS, including acylation, nitrosylation, phosphorylation, acetylation, glycosylation and glutathionylation. Sites, mediators and impact on enzyme localization and activity of the single modifications will be discussed. Moreover, interdependence, cooperativity and competition between the different posttranslational modifications will be elaborated with special emphasis on the susceptibility of eNOS to metabolic cues.
Keywords: Endothelial NO synthase, regulation of enzyme activity, posttranslational modification.
Current Pharmaceutical Design
Title:Regulation of eNOS Enzyme Activity by Posttranslational Modification
Volume: 20 Issue: 22
Author(s): Elke H. Heiss and Verena M. Dirsch
Affiliation:
Keywords: Endothelial NO synthase, regulation of enzyme activity, posttranslational modification.
Abstract: The regulation of endothelial NO synthase (eNOS) employs multiple different cellular control mechanisms impinging on level and activity of the enzyme. This review aims at summarizing the current knowledge on the posttranslational modifications of eNOS, including acylation, nitrosylation, phosphorylation, acetylation, glycosylation and glutathionylation. Sites, mediators and impact on enzyme localization and activity of the single modifications will be discussed. Moreover, interdependence, cooperativity and competition between the different posttranslational modifications will be elaborated with special emphasis on the susceptibility of eNOS to metabolic cues.
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Cite this article as:
Heiss H. Elke and Dirsch M. Verena, Regulation of eNOS Enzyme Activity by Posttranslational Modification, Current Pharmaceutical Design 2014; 20 (22) . https://dx.doi.org/10.2174/13816128113196660745
DOI https://dx.doi.org/10.2174/13816128113196660745 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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