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Letters in Drug Design & Discovery

Editor-in-Chief

ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Improved Synthesis of Antiviral Drug Valacyclovir Hydrochloride

Author(s): Keshava Navin Kumar Reddy, Murugulla Adharvana Chari, Mayur. D. Khunt, B. Ramachandra Reddy, Vurimidi Himabindu and Ghanta Mahesh Reddy

Volume 11 , Issue 4 , 2014

Page: [484 - 487] Pages: 4

DOI: 10.2174/15701808113106660090

Price: $65

Abstract

A cost-effective and improved process was developed for the synthesis of the antiviral drug Valacyclovir hydrochloride 1. The process involves the Streglich condensation between 4 and 6 to obtain N-Phthalimide-L-Valine ester 5, which was deprotected by using 40% monomethylamine Overall, the chemistry has been developed and used to prepare Valacyclovir drug 1 in an overall yield of 61 %.

Keywords: Valacyclovir hydrochloride, Antiviral drug, Improved synthesis, N-Phthalimide-L-Valine ester, Monomethylamine, commercially scalable process, Less cycle time.

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