Improved Synthesis of Antiviral Drug Valacyclovir Hydrochloride

Title:Improved Synthesis of Antiviral Drug Valacyclovir Hydrochloride

Volume: 11 Issue: 4

Author(s): Keshava Navin Kumar Reddy, Murugulla Adharvana Chari, Mayur. D. Khunt, B. Ramachandra Reddy, Vurimidi Himabindu and Ghanta Mahesh Reddy

Affiliation:

Keywords: Valacyclovir hydrochloride, Antiviral drug, Improved synthesis, N-Phthalimide-L-Valine ester, Monomethylamine, commercially scalable process, Less cycle time.

Abstract: A cost-effective and improved process was developed for the synthesis of the antiviral drug Valacyclovir hydrochloride 1. The process involves the Streglich condensation between 4 and 6 to obtain N-Phthalimide-L-Valine ester 5, which was deprotected by using 40% monomethylamine Overall, the chemistry has been developed and used to prepare Valacyclovir drug 1 in an overall yield of 61 %.

Cite this article as:

Reddy Navin Kumar Keshava, Chari Adharvana Murugulla, Khunt D. Mayur., Reddy Ramachandra B., Himabindu Vurimidi and Reddy Mahesh Ghanta, Improved Synthesis of Antiviral Drug Valacyclovir Hydrochloride, Letters in Drug Design & Discovery 2014; 11 (4) . https://dx.doi.org/10.2174/15701808113106660090