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Letters in Drug Design & Discovery


ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Synthesis and Antibacterial Activity of Novel Chalcone Derivatives of Apocynin

Author(s): P. Janaki, B. Bhadraiah, P. Acharya Nagarjuna and N. J. P. Subhashini

Volume 10, Issue 10, 2013

Page: [923 - 927] Pages: 5

DOI: 10.2174/15701808113109990081

Price: $65


A series of novel chalcones 1a- 1l (12 compounds) has been synthesized by using commercially available apocynin and aromatic aldehydes. The newly synthesized chalcone derivatives were screened for their antibacterial activities against gram positive and gram negative bacteria at the concentrations 10 of μg/mL with reference to the standard antibacterial drug Gentamycin. The screening results revealed that among the tested analogs, compounds having the hetero rings such as benzo[b]furan, furan and pyridine (1j,1k and 1l) in the structure exhibited excellent antibacterial activity while the compounds bearing fluorine, 2-CF3, 4-CF3 and 4-OCF3 (1f, 1g, 1h and 1i) also exhibited good to excellent activity.

Keywords: Chalcones, Apocynin, Aldehydes, Synthesis, Gram positive, antibacterial activity.

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