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Current Organocatalysis


ISSN (Print): 2213-3372
ISSN (Online): 2213-3380

L-Proline Catalyzed Synthesis of Structurally Diverse 1,4- dihydropyridines Fused with Medicinally Privileged Heterocyclic Systems

Author(s): Sarita Khandelwal, Anshu Rajawat and Mahendra Kumar

Volume 1 , Issue 1 , 2014

Page: [51 - 58] Pages: 8

DOI: 10.2174/22133372114016660004


Structurally diverse unsymmetrically annulated 1,4-dihydropyridines have been synthesized by L-proline catalyzed four-component domino protocol involving the reaction of 2-aminobenzothiazole, thiophene-2-carbaldehyde and carbonyl compounds in ethanol. The utilization of L-proline in the multicomponent reaction will make the present protocol attractive for synthesis of 1,4-dihydropyridines in terms of reaction efficiency, atom-economy and environmental safety.

Keywords: 2-aminobenzothiazole, 1, 4-dihydropyridines, chromenoindenopyridines, chromenoquinolines, indenoquinolines, Knoevenagel condensation, medicinally privileged heterocycles, Michael addition, multicomponent reaction, organocatalysis, L-proline, pyranoquinolines.

Graphical Abstract

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