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Current Metabolomics

Editor-in-Chief

ISSN (Print): 2213-235X
ISSN (Online): 2213-2368

NMR Metabolomics Analysis of Parkinson's Disease

Author(s): Shulei Lei and Robert Powers

Volume 1 , Issue 3 , 2013

Page: [191 - 209] Pages: 19

DOI: 10.2174/2213235X113019990004

Abstract

Parkinson's disease (PD) is a neurodegenerative disease, which is characterized by progressive death of dopaminergic neurons in the substantia nigra pars compacta. Although mitochondrial dysfunction and oxidative stress are linked to PD pathogenesis, its etiology and pathology remain to be elucidated. Metabolomics investigates metabolite changes in biofluids, cell lysates, tissues and tumors in order to correlate these metabolomic changes to a disease state. Thus, the application of metabolomics to investigate PD provides a systematic approach to understand the pathology of PD, to identify disease biomarkers, and to complement genomics, transcriptomics and proteomics studies. This review will examine current research into PD mechanisms with a focus on mitochondrial dysfunction and oxidative stress. Neurotoxin- based PD animal models and the rationale for metabolomics studies in PD will also be discussed. The review will also explore the potential of NMR metabolomics to address important issues related to PD treatment and diagnosis.


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