Abstract
Pancreatic cancer is a devastating malignancy with a median survival of less than one year. The exceedingly poor prognosis for metastatic pancreatic cancer patients remains a significant unmet medical need and is an opportunity for development of novel therapeutic approaches incorporating gene therapy strategies. Barriers exist preventing effective gene therapy including low transfection efficiency, poor tissue penetrance as well as non-specific delivery. However, one specific strategy using synthetic short interfering RNA fragments holds great potential and recently demonstrated successful systemic delivery using a transferrin (Tf)-targeted cyclodextrin-based polymer nanoparticle. Various nanoparticle formulations are currently being optimized for systemic gene therapy approaches. In this review, we highlight the rapidly progressing field of gene therapy strategies that have the potential to enhance the care of patients with devastating malignancies such as pancreatic cancer and focus on systemic delivery strategies to overcome remaining hurdles limiting widespread clinical applications.
Keywords: Gene therapy, Short interfering RNA fragment, Nanoparticle, Pancreatic cancer.
Current Cancer Therapy Reviews
Title:Optimizing Gene Silencing Strategies for Pancreatic Cancer
Volume: 9 Issue: 2
Author(s): Ernest Ramsay Camp, Katie Hurst, Cindy Wang, David J. Cole and Dennis K. Watson
Affiliation:
Keywords: Gene therapy, Short interfering RNA fragment, Nanoparticle, Pancreatic cancer.
Abstract: Pancreatic cancer is a devastating malignancy with a median survival of less than one year. The exceedingly poor prognosis for metastatic pancreatic cancer patients remains a significant unmet medical need and is an opportunity for development of novel therapeutic approaches incorporating gene therapy strategies. Barriers exist preventing effective gene therapy including low transfection efficiency, poor tissue penetrance as well as non-specific delivery. However, one specific strategy using synthetic short interfering RNA fragments holds great potential and recently demonstrated successful systemic delivery using a transferrin (Tf)-targeted cyclodextrin-based polymer nanoparticle. Various nanoparticle formulations are currently being optimized for systemic gene therapy approaches. In this review, we highlight the rapidly progressing field of gene therapy strategies that have the potential to enhance the care of patients with devastating malignancies such as pancreatic cancer and focus on systemic delivery strategies to overcome remaining hurdles limiting widespread clinical applications.
Export Options
About this article
Cite this article as:
Camp Ramsay Ernest, Hurst Katie, Wang Cindy, Cole David J. and Watson K. Dennis, Optimizing Gene Silencing Strategies for Pancreatic Cancer, Current Cancer Therapy Reviews 2013; 9 (2) . https://dx.doi.org/10.2174/1573394711309020004
DOI https://dx.doi.org/10.2174/1573394711309020004 |
Print ISSN 1573-3947 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6301 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Natural Molecules as Talented Inhibitors of Nucleotide Pyrophosphatases/
Phosphodiesterases (PDEs)
Current Topics in Medicinal Chemistry The Epidemiology and Health Effects of Tobacco Use
Current Pediatric Reviews Potentials and Challenges of Active Targeting at the Tumor Cells by Engineered Polymeric Nanoparticles
Current Pharmaceutical Biotechnology Nitric Oxide in Cancer Therapeutics: Interaction with Cytotoxic Chemotherapy
Current Pharmaceutical Design Pathophysiology of IgG4-Related Disease
Current Immunology Reviews (Discontinued) Monoclonal Antibodies in the Management of Solid Tumors
Current Topics in Medicinal Chemistry ras Genes and Human Cancer: Different Implications and Different Roles
Current Genomics Application of Efficient Nanoparticles for Early Diagnosis and Treatment of Cancer
Current Drug Metabolism Relevance of the Chronobiological and Non-chronobiological Actions of Melatonin for Enhancing Therapeutic Efficacy in Neurodegenerative Disorders
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery A Novel Approach to Inhibit Heat Shock Response as Anticancer Strategy by Coumarine Compounds Containing Thiazole Skeleton
Anti-Cancer Agents in Medicinal Chemistry Clinical Use of Therapies Targeting Tumor Vasculature and Stroma
Current Cancer Drug Targets Virtual Screening of Potential Anti-fatigue Mechanism of Polygonati Rhizoma Based on Network Pharmacology
Combinatorial Chemistry & High Throughput Screening Exosomes Harnessed as Nanocarriers for Cancer Therapy - Current Status and Potential for Future Clinical Applications
Current Molecular Medicine Pharmacological Effect of Berberine Chloride in Propyl Thiouracil Induced Thyroidal Dysfunction - A Time Bound Study in Female Rats
Recent Patents on Drug Delivery & Formulation Co-delivery of Plasmid DNA and Antisense Oligodeoxyribonucleotide into Human Carcinoma Cells by Cationic Liposomes
Current Pharmaceutical Biotechnology Natural Products as Anti-Cancerous Therapeutic Molecules Targeted towards Topoisomerases
Current Protein & Peptide Science A Review on Exploring Better Safety Prospects in Managing Cancer using Liposomal Combinations of Food Bioactive Compounds and Anticancer Drugs: Combisomes
Current Drug Delivery Opportunities for Photoacoustic-Guided Drug Delivery
Current Drug Targets Tumor Stroma Manipulation By MSC
Current Drug Targets Soluble Epoxide Hydrolase Inhibitors and their Potential for Treatment of Multiple Pathologic Conditions
Current Medicinal Chemistry