Abstract
Vildagliptin-loaded mucoadhesive nanoparticles using Carbopol 934 P (CVN) as mucoadhesive polymer were prepared by Buchi Nano Spray Dryer to retain the drug in the stomach for a prolonged period of time and to provide sustainable release. The morphological properties of the nanoparticles were studied by scanning electron microscopy and found to have smoother surface with shriveled shape. Drug loading and the percentage recovery werefound to be 89.2 ± 0.5 and 96 ± 0.4 respectively. Bimodal particle size distribution with a mean of 355.8 nm and 80.15 nm was noticed. Angle of repose for CVN particles was relatively good with θ < 32.4°. The percent swelling of CVN formulation was found to be 181±9%. In vivo studies in rats suggest that the vildagliptin was retained in the gastrointestinal tract(GIT) for prolonged period of time (~12 h) and standard group was reduced significantly (~3 h). Stability studies witnessed no changes when stored at 3-5°C or 15 – 25°C, except that the agglutinative phenomenon which was observed at 37°C and RH 75%. This study validates the mucoadhesive nanoparticles as one of the most appropriate drug delivery approaches for the effective delivery of vildagliptin.
Keywords: Nanoparticles, vildagliptin, spraydrying, diabetic, carbopol, shriveled.
Current Nanoscience
Title:Carbopol 934-P Loaded with Vildagliptin for Diabetic Delivery: In Vitro and In Vivo Evaluation of Nanoparticles
Volume: 9 Issue: 5
Author(s): Sree Harsha N, Bander E. Aldhubiab, Ibrahim Abdulrahman Alhaider, Mahesh Attimarad and Anroop Nair
Affiliation:
Keywords: Nanoparticles, vildagliptin, spraydrying, diabetic, carbopol, shriveled.
Abstract: Vildagliptin-loaded mucoadhesive nanoparticles using Carbopol 934 P (CVN) as mucoadhesive polymer were prepared by Buchi Nano Spray Dryer to retain the drug in the stomach for a prolonged period of time and to provide sustainable release. The morphological properties of the nanoparticles were studied by scanning electron microscopy and found to have smoother surface with shriveled shape. Drug loading and the percentage recovery werefound to be 89.2 ± 0.5 and 96 ± 0.4 respectively. Bimodal particle size distribution with a mean of 355.8 nm and 80.15 nm was noticed. Angle of repose for CVN particles was relatively good with θ < 32.4°. The percent swelling of CVN formulation was found to be 181±9%. In vivo studies in rats suggest that the vildagliptin was retained in the gastrointestinal tract(GIT) for prolonged period of time (~12 h) and standard group was reduced significantly (~3 h). Stability studies witnessed no changes when stored at 3-5°C or 15 – 25°C, except that the agglutinative phenomenon which was observed at 37°C and RH 75%. This study validates the mucoadhesive nanoparticles as one of the most appropriate drug delivery approaches for the effective delivery of vildagliptin.
Export Options
About this article
Cite this article as:
N Harsha Sree, Aldhubiab E. Bander, Alhaider Abdulrahman Ibrahim, Attimarad Mahesh and Nair Anroop, Carbopol 934-P Loaded with Vildagliptin for Diabetic Delivery: In Vitro and In Vivo Evaluation of Nanoparticles, Current Nanoscience 2013; 9 (5) . https://dx.doi.org/10.2174/15734137113099990086
DOI https://dx.doi.org/10.2174/15734137113099990086 |
Print ISSN 1573-4137 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6786 |
Call for Papers in Thematic Issues
Role of nanomaterials in fabrication of coatings, Machining and Joining
The application of nanoscience has brought about a revolution in the field of mechanical engineering by providing novel materials, boosting manufacturing processes, and generating cutting-edge products. The purpose of this special issue is to investigate the enormous impact that nanoscience has had on mechanical engineering, with a particular emphasis on ...read more
Advanced Inorganic Nanocomposites and Their Emerging Applications
This special issue collection will highlight developments on the recent trends about the synthesis of metal oxides, nanoclusters, biomaterials, 2D nanomaterials, nanocrystals, nanocomposites, etc. and their applications in electrochemical systems, tissue regeneration, energy storage and harvesting, sensors, etc. The novelty of the methods in the chemical synthesis and their characterizations, ...read more
Applicability of Nanotechnology for Performance Enhancement of Clean Energy Technologies
Population growth, industrialization, and improvement in living quality would lead to further increase in energy demand in near future. Regarding the disadvantages of fossil fuels such as fluctuations in their price, high emissions of greenhouse gases and restriction of their sources, it is crucial to use and exploit alternative energy ...read more
Graphene and 2D Materials for Energy Storage and Conversion
This thematic issue will discuss the recent advances in graphene-based nanomaterials for different energy technologies. Graphene possesses a high surface area, and stable structure and exhibits many interesting electronic, optical, and mechanical properties due to its 2D crystal structure. Graphene is of both fundamental interest and suitable for a wide ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Therapeutic Peptide Mimetics Looking for a Turn to Block Aberrant Players of Malignancy
Current Cancer Therapy Reviews In Vivo Target Validation: Methodology and Case Studies on the Janus Kinase Tyk2
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Bioactive Natural Compounds from the Mangrove Endophytic Fungi
Mini-Reviews in Medicinal Chemistry Virally Encoded G Protein-Coupled Receptors: Targets for Potentially Innovative Anti-Viral Drug Development
Current Drug Targets RNA Splicing Manipulation: Strategies to Modify Gene Expression for a Variety of Therapeutic Outcomes
Current Gene Therapy MicroRNA Gene Networks in Oncogenesis
Current Genomics Multifunctional Anti-Cancer Nano-Platforms are Moving to Clinical Trials
Current Drug Metabolism Quercetin-Decorated Curcumin Liposome Design for Cancer Therapy: In-Vitro and In-Vivo Studies
Current Drug Delivery The Polyhedric Abl Kinases and their Pharmacologic Inhibitors
Current Enzyme Inhibition CDC25 Phosphatase Inhibitors: An Update
Mini-Reviews in Medicinal Chemistry Medicinal Chemistry Insights into Novel HDAC Inhibitors: An Updated Patent Review (2012-2016)
Recent Patents on Anti-Cancer Drug Discovery Extracts of <i>Anogeissus leiocarpus and Dillenia indica</i> Inhibit the Growth of MCF-7 Breast Cancer and COV434 Granulosa Tumor Cells by Inducing Apoptosis and Autophagy
Current Bioactive Compounds Targeted – Therapy and Imaging Response: A New Paradigm For Clinical Evaluation?
Reviews on Recent Clinical Trials Computational Approaches for Predicting Causal Missense Mutations in Cancer Genome Projects
Current Bioinformatics Role of Secondary Alcohol Metabolites in Anthracycline Cardiotoxicity: from Hypotheses to New Drugs
Drug Design Reviews - Online (Discontinued) Safer Vectors for Gene Therapy of Primary Immunodeficiencies
Current Gene Therapy Hematotoxicity Testing by Cell Clonogenic Assay in Drug Development and Preclinical Trials
Current Pharmaceutical Design The Effects of Cantharidin and Cantharidin Derivates on Tumour Cells
Anti-Cancer Agents in Medicinal Chemistry Molecular Targeting of Protein Kinases to Optimize Selectivity and Resistance Profiles of Kinase Inhibitors
Current Topics in Medicinal Chemistry Development of Patents and Clinical Trials on Regenerative Therapy: Gene Therapy
Recent Patents on Regenerative Medicine