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Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

In Vitro and In Vivo Models for Analysis of Resistance to Anticancer Molecular Therapies

Author(s): Roberta Rosa, Francesca Monteleone, Nicola Zambrano and Roberto Bianco

Volume 21 , Issue 14 , 2014

Page: [1595 - 1606] Pages: 12

DOI: 10.2174/09298673113209990226

Abstract

The efficacy of classical and molecular therapies in cancer is hampered by the occurrence of primary (intrinsic) and secondary (acquired) refractoriness of tumours to selected therapeutic regimens. Nevertheless, the increased knowledge of the genetic, molecular and metabolic mechanisms underlying cancer results in the generation of a correspondingly increasing number of druggable targets and molecular drugs. Thus, a current challenge in molecular oncology and medicinal chemistry is to cope with the increased need for modelling, both in cellular and animal systems, the genetic assets associated to cancer resistance to drugs. In this review, we summarize the current strategies for generation and analysis of in vitro and in vivo models, which may reveal useful to extract information on the molecular basis of intrinsic and acquired resistance to anticancer molecular agents.

Keywords: Anticancer molecular therapies, tumour, molecular modelling.


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