Carbasugar Probes to Explore the Enzyme Binding Pocket at the Anomeric Position: Application to the Design of Golgi Mannosidase II Inhibitors

Title:Carbasugar Probes to Explore the Enzyme Binding Pocket at the Anomeric Position: Application to the Design of Golgi Mannosidase II Inhibitors

Volume: 20 Issue: 30

Author(s): M. V. Vinader and K. Afarinkia

Affiliation:

• Institute of Cancer Therapeutics, University of Bradford, Bradford, BD7 1DP, United Kingdom.,United Kingdom

Keywords: Carbasugar, Golgi mannosidase II, molecular modelling, synthesis.

Abstract: A methodology is described for the highly efficient and divergent synthesis of pseudosugars which allows the stereoselective introduction of polar groups at either the α or the β pseudoanomeric positions. Using this method, a series of 3-deoxycarbasugar analogues of mannose bearing a pyridyl group are rationally designed, prepared and tested for inhibition of Golgi α-mannosidase II.

Cite this article as:

Vinader V. M. and Afarinkia K., Carbasugar Probes to Explore the Enzyme Binding Pocket at the Anomeric Position: Application to the Design of Golgi Mannosidase II Inhibitors, Current Medicinal Chemistry 2013; 20(30) . https://dx.doi.org/10.2174/09298673113209990180