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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Carbasugar Probes to Explore the Enzyme Binding Pocket at the Anomeric Position: Application to the Design of Golgi Mannosidase II Inhibitors

Author(s): M. V. Vinader and K. Afarinkia

Volume 20 , Issue 30 , 2013

Page: [3797 - 3801] Pages: 5

DOI: 10.2174/09298673113209990180

Price: $65


A methodology is described for the highly efficient and divergent synthesis of pseudosugars which allows the stereoselective introduction of polar groups at either the α or the β pseudoanomeric positions. Using this method, a series of 3-deoxycarbasugar analogues of mannose bearing a pyridyl group are rationally designed, prepared and tested for inhibition of Golgi α-mannosidase II.

Keywords: Carbasugar, Golgi mannosidase II, molecular modelling, synthesis.

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