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Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Sulfur-based Mechanistic Probes for Enzyme-catalyzed Reactions

Author(s): Weiping Zheng

Volume 20 , Issue 30 , 2013

Page: [3743 - 3758] Pages: 16

DOI: 10.2174/09298673113209990177

Price: $65

Abstract

Sulfur (S), as the second element in the main group 6A just below oxygen (O), has been often used as an isosteric replacement for O in enzymatic mechanistic studies. In addition, S has also been used as an isosteric replacement for CH2. These S-based mechanistic probes have been used in the studies with protein enzyme systems such as the sirtuin family of the protein Nε-acyl-lysine deacylases, phosphotransferases, and fatty acid desaturase, as well as various RNA enzymes (ribozymes). These probes are basically the O→S mutants of the corresponding O(or CH2)-containing substrates for the enzymatic reactions under study. This article will review the significant contributions that the S-based probes have been able to make toward an enhanced mechanistic understanding of different types of the enzyme-catalyzed reactions.

Keywords: Sulfur-based, mechanistic probes, enzymatic reactions.


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