Synthesis of Methylenebisamides by TFA-Promoted Reactions of Nitriles and DMSO

Title:Synthesis of Methylenebisamides by TFA-Promoted Reactions of Nitriles and DMSO

Volume: 10 Issue: 10

Author(s): Lingxia Pan, Lin Huang and Chunsong Xie

Affiliation:

Keywords: Methylenebisamide, nitrile, DMSO.

Abstract: Under TFA promoted conditions, aryl and 2-pyridyl nitriles can react with DMSO, affording methylenebisamides in moderate to good yields. While the electron-donating groups give good yields, the electron-withdrawing groups provide lower yields.

Cite this article as:

Pan Lingxia, Huang Lin and Xie Chunsong, Synthesis of Methylenebisamides by TFA-Promoted Reactions of Nitriles and DMSO, Letters in Organic Chemistry 2013; 10 (10) . https://dx.doi.org/10.2174/15701786113109990049