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Current Neuropharmacology

Editor-in-Chief

ISSN (Print): 1570-159X
ISSN (Online): 1875-6190

Neurodevelopment in Schizophrenia: The Role of the Wnt Pathways

Author(s): Elisa Ambrosi, Gabriele Sani, Paolo Girardi, Ferdinando Nicoletti, Marta Motolese, Delfina Janiri, Giovanni Manfredi, Emanuela Danese, Lavinia De Chiara, Valeria Savoja, Alessio Simonetti, Isabella Panaccione, Ilaria Cuomo, Federica Caccia, Daniele Serata, Chiara Brugnoli, Chiara Rapinesi, Antonio Del Casale, Giorgio D. Kotzalidis, Alberto Maria Forte and Flavia Napoletano

Volume 11 , Issue 5 , 2013

Page: [535 - 558] Pages: 24

DOI: 10.2174/1570159X113119990037

Price: $65

Abstract

Objectives. To review the role of Wnt pathways in the neurodevelopment of schizophrenia.

Methods: Systematic PubMed search, using as keywords all the terms related to the Wnt pathways and crossing them with each of the following areas: normal neurodevelopment and physiology, neurodevelopmental theory of schizophrenia, schizophrenia, and antipsychotic drug action.

Results: Neurodevelopmental, behavioural, genetic, and psychopharmacological data point to the possible involvement of Wnt systems, especially the canonical pathway, in the pathophysiology of schizophrenia and in the mechanism of antipsychotic drug action. The molecules most consistently found to be associated with abnormalities or in antipsychotic drug action are Akt1, glycogen synthase kinase3beta, and beta-catenin. However, the extent to which they contribute to the pathophysiology of schizophrenia or to antipsychotic action remains to be established.

Conclusions: The study of the involvement of Wnt pathway abnormalities in schizophrenia may help in understanding this multifaceted clinical entity; the development of Wnt-related pharmacological targets must await the collection of more data.

Keywords: Antipsychotic Drugs; Neurodevelopment; Schizophrenia; Wingless (Wnt) signalling.


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