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Current Protein & Peptide Science


ISSN (Print): 1389-2037
ISSN (Online): 1875-5550

Critical Aspects to be Considered Prior to Large-Scale Production of Peptides

Author(s): Kelly Cristina Leite Mulder, Antônio Américo Barbosa Viana, Mauro Xavier and Nádia Skorupa Parachin

Volume 14, Issue 7, 2013

Page: [556 - 567] Pages: 12

DOI: 10.2174/13892037113149990071

Price: $65


Numerous peptides are available on the market as therapeutic drugs for regulating tumor growth, microorganism proliferation, immune response and/or metabolic disorders. Peptides are produced either by chemical synthesis or heterologous expression. Independent of the method chosen, there are challenges to transferring its production from the bench (~mg/L) to the industrial (~g/L) scale. Thus, the main scale-up pitfalls for the two methods of peptide production are reviewed here, including the advantages of each. Moreover, there will be a special focus on the main challenges for large-scale, heterologous production systems. Peptides that are currently available on the market are also described with an emphasis on how their process optimization has been designed in order to develop a cost-effective product.

Keywords: Calcitonin, chemical synthesis, Fuzeon, Glucagon, heterologous expression, Pexiganan, Sandostatin, scale-up.

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