Abstract
L-Proline is a cheap, water-soluble organocatalyst that is able to induce the synthesis of a large number of heterocyclic systems. This work is reviewed, with emphasis on the literature of the 2005-2011 period. The domino reactions have been classified according to the nature of the first step of their proposed mechanisms, as follows: (i) iminium-initiated domino mechanisms; (ii) enamineinitiated domino mechanisms; (iii) reactions proceeding via the intermediacy of dienamines; (iv) reactions in which proline acts as a Lewis base and (v) L-proline/metal catalysed reactions.
Keywords: L-proline, organocatalyst, multicomponent, domino, synthesis, heterocycles.
Current Organic Chemistry
Title:L-Proline Catalysed Domino Reactions for the Synthesis of Heterocycles
Volume: 17 Issue: 18
Author(s): Sethuraman Indumathi, Jose C. Menendez and Subbu Perumal
Affiliation:
Keywords: L-proline, organocatalyst, multicomponent, domino, synthesis, heterocycles.
Abstract: L-Proline is a cheap, water-soluble organocatalyst that is able to induce the synthesis of a large number of heterocyclic systems. This work is reviewed, with emphasis on the literature of the 2005-2011 period. The domino reactions have been classified according to the nature of the first step of their proposed mechanisms, as follows: (i) iminium-initiated domino mechanisms; (ii) enamineinitiated domino mechanisms; (iii) reactions proceeding via the intermediacy of dienamines; (iv) reactions in which proline acts as a Lewis base and (v) L-proline/metal catalysed reactions.
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Cite this article as:
Indumathi Sethuraman, Menendez C. Jose and Perumal Subbu, L-Proline Catalysed Domino Reactions for the Synthesis of Heterocycles, Current Organic Chemistry 2013; 17 (18) . https://dx.doi.org/10.2174/13852728113179990096
DOI https://dx.doi.org/10.2174/13852728113179990096 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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