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Current Organic Chemistry

Editor-in-Chief

ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

L-Proline Catalysed Domino Reactions for the Synthesis of Heterocycles

Author(s): Sethuraman Indumathi, Jose C. Menendez and Subbu Perumal

Volume 17, Issue 18, 2013

Page: [2038 - 2064] Pages: 27

DOI: 10.2174/13852728113179990096

Price: $65

Abstract

L-Proline is a cheap, water-soluble organocatalyst that is able to induce the synthesis of a large number of heterocyclic systems. This work is reviewed, with emphasis on the literature of the 2005-2011 period. The domino reactions have been classified according to the nature of the first step of their proposed mechanisms, as follows: (i) iminium-initiated domino mechanisms; (ii) enamineinitiated domino mechanisms; (iii) reactions proceeding via the intermediacy of dienamines; (iv) reactions in which proline acts as a Lewis base and (v) L-proline/metal catalysed reactions.

Keywords: L-proline, organocatalyst, multicomponent, domino, synthesis, heterocycles.


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