Abstract
Gene therapy is a promising approach for disease prevention and therapy. Efficient gene delivery is an important factor limiting gene delivery. Due to the poor stability of nucleotide molecules in vivo, they require an association with delivery systems to overcome extracellular and intracellular barriers and allow access to the site of action. In this review, we discuss the challenges currently encountered in the delivery of DNA and RNAi-based therapies using the most common cationic polymer assemblies including polylysines, chitosan, polyethylenimines, dendrimers, cyclodextrins and illustrate with examples how chemical modification of cationic assemblies may contribute to their successful application in the clinic.
Keywords: Cationic assemblies, cationic polymers, complexes, DNA delivery, gene delivery, RNA interference, siRNA delivery.
Pharmaceutical Nanotechnology
Title:Current Trends in the Use of Cationic Polymer Assemblies for siRNA and Plasmid DNA Delivery
Volume: 1 Issue: 3
Author(s): Gemma Navarro, Sara Movassaghian and Vladimir P. Torchilin
Affiliation:
Keywords: Cationic assemblies, cationic polymers, complexes, DNA delivery, gene delivery, RNA interference, siRNA delivery.
Abstract: Gene therapy is a promising approach for disease prevention and therapy. Efficient gene delivery is an important factor limiting gene delivery. Due to the poor stability of nucleotide molecules in vivo, they require an association with delivery systems to overcome extracellular and intracellular barriers and allow access to the site of action. In this review, we discuss the challenges currently encountered in the delivery of DNA and RNAi-based therapies using the most common cationic polymer assemblies including polylysines, chitosan, polyethylenimines, dendrimers, cyclodextrins and illustrate with examples how chemical modification of cationic assemblies may contribute to their successful application in the clinic.
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Cite this article as:
Navarro Gemma, Movassaghian Sara and Torchilin P. Vladimir, Current Trends in the Use of Cationic Polymer Assemblies for siRNA and Plasmid DNA Delivery, Pharmaceutical Nanotechnology 2013; 1 (3) . https://dx.doi.org/10.2174/22117385113019990003
DOI https://dx.doi.org/10.2174/22117385113019990003 |
Print ISSN 2211-7385 |
Publisher Name Bentham Science Publisher |
Online ISSN 2211-7393 |
Call for Papers in Thematic Issues
Polymeric nanocarriers in drug delivery
Polymeric nanocarriers play a crucial role in drug delivery due to their versatility, and unique properties for targeting and modifying drug release. Their ability to enhance therapeutic outcomes, reduce side effects, and enable the delivery of drugs in a more targeted and controlled manner made them popular in the last ...read more
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