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Current Neurovascular Research


ISSN (Print): 1567-2026
ISSN (Online): 1875-5739

Cerebrovascular Damage as a Cause for Alzheimers Disease

Author(s): C. Humpel and J. Marksteiner

Volume 2, Issue 4, 2005

Page: [341 - 347] Pages: 7

DOI: 10.2174/156720205774322610

Price: $65


Alzheimers disease is a progressive brain disorder that gradually destroys a patients memory function and ability to carry out daily activities. According to the prevailing amyloid cascade hypothesis, Alzheimers disease is initiated by amyloid ß-peptide accumulation leading to neuronal toxicity. The neurofibrillary tangle deriving from hyperphosphorylated tau and synapse loss are also key features for Alzheimers disease. Recent studies revealed a significant comorbidity of Alzheimers disease and cerebrovascular disease suggesting that cerebrovascular dysregulation is an important feature of Alzheimers disease. This mini-review will discuss the hypothesis that a dysfunction of the vascular system may result in damage of the neurovascular unit, initiating a cascade of events. An overlap with other forms of cognitive impairment, such as mild cognitive impairment, or vascular dementia will be discussed.

Keywords: vascular system, alzheimer, vascular dementia, hypothesis, cascade

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