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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Development of Therapeutics for High Grade Gliomas Using Orthotopic Rodent Models

Author(s): Guido Frosina

Volume 20, Issue 26, 2013

Page: [3272 - 3299] Pages: 28

DOI: 10.2174/0929867311320260011

Price: $65


To study novel treatments for high grade gliomas (WHO grade III and IV) we need animal models of those disorders. Orthotopic tumors in mouse or rats seem at present the most reliable in vivo glioma model in order to develop specific therapies. The orthotopic tumor characteristics should yet closely mimic the human glioma features (in particular infiltrating growth and neovascularization). In this regard, glioma cell lines with stem properties (glioma stem cells – GSC) may fulfill at best those needs. Orthotopic gliomas developed from some widely used, established non-stem cell lines showing poor infiltrating capacity are not suitable. Therapeutic and diagnostic procedures recently developed using orthotopic rodent glioma tumors along their potentialities and pitfalls are analyzed.

Keywords: Brain tumor, radiotherapy, temozolomide, glioblastoma, cell cycle, resistance and in vivo.

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