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Combinatorial Chemistry & High Throughput Screening


ISSN (Print): 1386-2073
ISSN (Online): 1875-5402

A Passerini-Type Condensation: A Carboxylic Acid-Free Approach for the Synthesis of the α-Acyloxycarboxamides

Author(s): Mojtaba Mahyari, Shabnam Shaabani, Ahmad Shaabani and Seik Weng Ng

Volume 16 , Issue 10 , 2013

Page: [858 - 864] Pages: 7

DOI: 10.2174/13862073113169990051

Price: $65


A Passerini-type condensation for the synthesis of α-acyloxycarboxamides starting from simple and readily available inputs, including an isocyanide, aldehydes and water in the presence of trimethylsilyl azide as a catalyst under reflux conditions in toluene in good yields, is described.

Keywords: Isocyanide, Passerini reaction, α-acyloxycarboxamides.

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