Generic placeholder image

Combinatorial Chemistry & High Throughput Screening


ISSN (Print): 1386-2073
ISSN (Online): 1875-5402

Facile and Efficient Synthesis of New Class of Imidazole Derivatives via One-Pot Multicomponent Reactions in Water

Author(s): Zinatossadat Hossaini, Samereh Seyfi, Faramarz Rostami-Charati and Mehdi Ghambarian

Volume 16 , Issue 10 , 2013

Page: [788 - 790] Pages: 3

DOI: 10.2174/13862073113169990046

Price: $65


A water-accelerated multicomponent synthesis of organic target molecules has been used as a key method for the preparation of novel imidazole derivatives. The three-component condensation reactions of primary amines with trichloroacetonitrile in the presence of ninhydrine in water are developed as efficient and clean green synthetic procedures for the high-yielding preparation of imidazoles.

Keywords: Indenoimidazole, Ninhydrine, Primary amines, three-component reaction, trichloroacetonitrile.

Rights & Permissions Print Export Cite as
© 2022 Bentham Science Publishers | Privacy Policy