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Combinatorial Chemistry & High Throughput Screening

Editor-in-Chief

ISSN (Print): 1386-2073
ISSN (Online): 1875-5402

Facile and Efficient Synthesis of New Class of Imidazole Derivatives via One-Pot Multicomponent Reactions in Water

Author(s): Zinatossadat Hossaini, Samereh Seyfi, Faramarz Rostami-Charati and Mehdi Ghambarian

Volume 16 , Issue 10 , 2013

Page: [788 - 790] Pages: 3

DOI: 10.2174/13862073113169990046

Price: $65

Abstract

A water-accelerated multicomponent synthesis of organic target molecules has been used as a key method for the preparation of novel imidazole derivatives. The three-component condensation reactions of primary amines with trichloroacetonitrile in the presence of ninhydrine in water are developed as efficient and clean green synthetic procedures for the high-yielding preparation of imidazoles.

Keywords: Indenoimidazole, Ninhydrine, Primary amines, three-component reaction, trichloroacetonitrile.


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