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Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Review Article

Recent Advances in Fluorescent Probes for Monitoring of Hydrogen Sulfide

Author(s): Cun-Xian Duan and Yu-Guo Liu

Volume 20 , Issue 23 , 2013

Page: [2929 - 2937] Pages: 9

DOI: 10.2174/09298673113209990005

Price: $65

Abstract

Hydrogen sulfide (H2S), known for its unpleasant rotten egg smell and its high toxicity, has recently emerged as an important mediator of human physiological and pathological processes, such as the regulation of cell growth, cardiovascular protection, the stimulation of angiogenesis, gastric mucosal injury and Alzheimer’s disease. Due to its significant actions in the physiology, H2S has attracted the abundant concern of numerous researchers in the cutting edge of chemistry, biology and medicine. Recently, several fluorescent probes have been developed for detecting and elucidating the role played by H2S in biological systems. This review highlights recent advances that have been made on the mechanism and applications of fluorescent probes for the detection of H2S, demonstrating a new field in which remarkable improvements have been accomplished over the last two years.

Keywords: Reactive sulfur species, hydrogen sulfide, fluorescent probes.


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