Abstract
Enantioselective epoxidation of olefins is a useful synthetic route in organic synthesis, as a wide variety of olefins is available and optically active epoxides can be converted into various functionalities with high regio- and stereoselectivity. Chiral manganese(III)- salen catalyst, which is commonly known as the Jacobson-Katsuki catalyst, has been reported as selective and efficient catalyst for the epoxidation of unfunctionalised alkenes in homogeneous phase, using a wide range of oxidants-iodosylbenzene, sodium hypochlorite, mchloroperoxybenzoic acid, hydrogen peroxide, etc. However, this homogeneous catalyst cannot be separated from the reaction media and, subsequently, cannot be recycled. Moreover, it suffers deactivation in homogeneous phase by formation of dimeric µ-oxo-manganese(IV) species, which are inactive in the alkene epoxidation. One way of improving the chemical process, preventing the requirement for a laborious and inefficient extraction processes, is to immobilize the homogeneous catalyst on a solid support. Numerous accounts for salen immobilization using diverse kinds of inorganic materials, organic materials and inorganic-organic hybrid materials have been firstly outlined in this review.
Keywords: Chirality, enantioselective epoxidation, immobilization, manganese, salen, selectivity.
Graphical Abstract
Call for Papers in Thematic Issues
Exploring the Role of Chemical Graph Theory in Advancing Current Organic Synthesis
Organic synthesis is a fundamental discipline in chemistry, crucial for the creation of complex molecules with diverse applications in pharmaceuticals, materials science, and beyond. However, the process of designing efficient synthetic routes for target molecules remains challenging. Chemical graph theory, a branch of theoretical chemistry, offers powerful tools for understanding ...read more
Photoswitches for Molecular Recognition
This Special Issue would cover the hot topics on synthesis and chemical and photophysical characterization of new photoswitchable derivatives and their applications on molecular recognition of metabolites and biological active compounds, both in physiological medium and in living cells. Photoswitches are compounds that can change their conformation or properties in ...read more
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