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Combinatorial Chemistry & High Throughput Screening

Editor-in-Chief

ISSN (Print): 1386-2073
ISSN (Online): 1875-5402

A Novel Three-Component Reaction for the Synthesis of 1,3-Benzoxazines in Water

Author(s): Faramarz Rostami-Charati

Volume 16 , Issue 10 , 2013

Page: [840 - 844] Pages: 5

DOI: 10.2174/1386207311301010009

Price: $65

Abstract

A simple and proficient method for the synthesis of 1,3-benzoxazine derivatives via three-component reaction of isocyanide and isoquinoline with 1-(6-hydroxy-2-isopropenyl-1-benzofuran-yl)-1-ethanone or 4-hydroxycumarine in water in the presence of piperidine at 70°C is reported.

Keywords: 1-(6-hydroxy-2-isopropenyl-1-benzofuran-yl)-1-ethanone, 1, 3-benzoxazine, Isocyanide, isoquinoline, threecomponent reaction.


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