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Current Organic Chemistry


ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

Superheated Water as Solvent in Microwave Assisted Organic Synthesis of Compounds of Valuable Pharmaceutical Interest

Author(s): Federica Messina and Ornelio Rosati

Volume 17, Issue 11, 2013

Page: [1158 - 1178] Pages: 21

DOI: 10.2174/1385272811317110004

Price: $65


According to the Green Chemistry principles, water is the first choice solvent to reduce chemical waste and environmental impact of chemical industry. Reaction in water can be improved when microwave irradiation is applied to a synthetic procedure due to the possibility to reach temperatures higher than the boiling point. This is especially true when reactions are carried out in superheated/ subcritical conditions (over 100 °C). In this paper, several synthetic procedures that use superheated or subcritical water as solvent in sealed vials under microwave irradiation as heating system, are reviewed. Noteworthy, the targets of these synthesis are valuable compounds of pharmaceutical interest.

Keywords: Green chemistry, Microwave, Subcritical, Superheated water.

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