Abstract
The biological roles of mitochondrial-produced reactive oxygen species continue to receive intensive investigation since one of the products (H2O2) has important cellular signaling roles as well as contributing to apoptotic responses. In general, the source of mitochondrial reactive oxygen species is thought to be the superoxide anion produced from Complex I and Complex III components of the electron transport chain. Superoxide anion readily dismutates to H2O2 with subsequent transformation to the hydroxyl radical by Fenton chemistry. An overlooked source of H2O2 in the mitochondrion is its production as a catalytic reaction product from the outer membrane enzymes: monoamine oxidases A and B. The literature is reviewed to document identified degenerative reactions attributed to H2O2 produced by MAO A and by MAO B catalysis. Available information on the topologies of these enzymes in the mitochondrial outer membrane is also discussed with relevance to H2O2 production and involvement in cell signaling functions as well as degenerative effects.
Keywords: Monoamine oxidases A and B, amine oxidation, mitochondrial outer membrane, mitochondrial intermembrane space, membrane topology, reactive oxygen species, hydrogen peroxide, hydroxyl radical.
Current Pharmaceutical Design
Title:Hydrogen Peroxide Produced by Mitochondrial Monoamine Oxidase Catalysis: Biological Implications
Volume: 20 Issue: 2
Author(s): Dale E. Edmondson
Affiliation:
Keywords: Monoamine oxidases A and B, amine oxidation, mitochondrial outer membrane, mitochondrial intermembrane space, membrane topology, reactive oxygen species, hydrogen peroxide, hydroxyl radical.
Abstract: The biological roles of mitochondrial-produced reactive oxygen species continue to receive intensive investigation since one of the products (H2O2) has important cellular signaling roles as well as contributing to apoptotic responses. In general, the source of mitochondrial reactive oxygen species is thought to be the superoxide anion produced from Complex I and Complex III components of the electron transport chain. Superoxide anion readily dismutates to H2O2 with subsequent transformation to the hydroxyl radical by Fenton chemistry. An overlooked source of H2O2 in the mitochondrion is its production as a catalytic reaction product from the outer membrane enzymes: monoamine oxidases A and B. The literature is reviewed to document identified degenerative reactions attributed to H2O2 produced by MAO A and by MAO B catalysis. Available information on the topologies of these enzymes in the mitochondrial outer membrane is also discussed with relevance to H2O2 production and involvement in cell signaling functions as well as degenerative effects.
Export Options
About this article
Cite this article as:
Edmondson E. Dale, Hydrogen Peroxide Produced by Mitochondrial Monoamine Oxidase Catalysis: Biological Implications, Current Pharmaceutical Design 2014; 20 (2) . https://dx.doi.org/10.2174/13816128113190990406
DOI https://dx.doi.org/10.2174/13816128113190990406 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
Call for Papers in Thematic Issues
"Tuberculosis Prevention, Diagnosis and Drug Discovery"
The Nobel Prize-winning discoveries of Mycobacterium tuberculosis and streptomycin have enabled an appropriate diagnosis and an effective treatment of tuberculosis (TB). Since then, many newer diagnosis methods and drugs have been saving millions of lives. Despite advances in the past, TB is still a leading cause of infectious disease mortality ...read more
Current Pharmaceutical challenges in the treatment and diagnosis of neurological dysfunctions
Neurological dysfunctions (MND, ALS, MS, PD, AD, HD, ALS, Autism, OCD etc..) present significant challenges in both diagnosis and treatment, often necessitating innovative approaches and therapeutic interventions. This thematic issue aims to explore the current pharmaceutical landscape surrounding neurological disorders, shedding light on the challenges faced by researchers, clinicians, and ...read more
Emerging and re-emerging diseases
Faced with a possible endemic situation of COVID-19, the world has experienced two important phenomena, the emergence of new infectious diseases and/or the resurgence of previously eradicated infectious diseases. Furthermore, the geographic distribution of such diseases has also undergone changes. This context, in turn, may have a strong relationship with ...read more
Melanoma and Non-Melanoma Skin Cancer Treatment: Standard of Care and Recent Advances
In this thematic issue, we aim to provide a standard of care of the diagnosis and treatment of melanoma and non-melanoma skin cancer. The editor will invite authors from different countries who will write review articles of melanoma and non-melanoma skin cancers. The Diagnosis, Staging, Surgical Treatment, Non-Surgical Treatment all ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Natural Products as Anti-Cancerous Therapeutic Molecules Targeted towards Topoisomerases
Current Protein & Peptide Science Cardiovascular Disease in Patients with Diabetic Nephropathy
Current Molecular Medicine Cardiotonic Steroids, Hypertension and Cardiovascular Disease
Current Hypertension Reviews Circadian Rhythm in Cytokines Administration
Mini-Reviews in Medicinal Chemistry Heart Transplantation in Biventricular Congenital Heart Disease: Indications, Techniques, and Outcomes
Current Cardiology Reviews Synthetic and Natural Protease Inhibitors Provide Insights into Parasite Development, Virulence and Pathogenesis
Current Medicinal Chemistry CD36 and Intestinal Fatty Acid Absorption
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Cell Death and Survival Through the Endoplasmic Reticulum- Mitochondrial Axis
Current Molecular Medicine Use of Peripheral Blood Stem Cells in Tissue Engineering
Current Tissue Engineering (Discontinued) Current Use of Cardiac Biomarkers in Various Heart Conditions
Endocrine, Metabolic & Immune Disorders - Drug Targets The Ryanodine Receptor: A Pivotal Ca2+ Regulatory Protein and Potential Therapeutic Drug Target
Current Drug Targets Study of Prolactin Permeation Through the Pericardium and Its Bioavailability
Protein & Peptide Letters The Role of iNOS in Chronic Inflammatory Processes In Vivo: Is it Damage-Promoting, Protective, or Active at all?
Current Molecular Medicine Recent advances in the management of autoimmune myocarditis: insights from animal studies.
Current Pharmaceutical Design Insights into the Relationship Between Hypertension and Albuminuria
Current Hypertension Reviews Anderson-Fabry Disease in Children
Current Pharmaceutical Design The Role of Integrin-Mediated Cell Adhesion in Atherosclerosis: Pathophysiology and Clinical Opportunities
Current Pharmaceutical Design Editorial: Perioperative Pharmacological Management: From Prescription Medications to Dietary Supplements
Current Clinical Pharmacology Inflamm-ageing and senescence in gout: the tale of an old king’s disease.
Current Aging Science Challenges in Managing Amniotic Fluid Embolism: An Up-to-Date Perspective on Diagnostic Testing with Focus on Novel Biomarkers and Avenues for Future Research
Current Pharmaceutical Biotechnology