Abstract
Thrombotic thrombocytopenic purpura (TTP) is a rare pediatric disease, yet has grave outcome if not managed properly. It shares many common clinical features with hemolytic uremic syndrome (HUS). While it is still disputable whether TTP and HUS are clinically related disorders, recent studies indicate that severe deficiency of a von Willebrand factor (vWF) cleaving protease is one of the primary causes of TTP. In this discussion, we will focus on TTP in reference to the deficiency of this protease, with the objective of increasing awareness among pediatric healthcare professionals of this less commonly recognized disease.
Keywords: Thrombotic thrombocytopenic purpura, hemolytic uremic syndrome, TTP, HUS.
Current Pediatric Reviews
Title:Thrombotic Thrombocytopenic Purpura, from the Perspectives of a Pediatrician
Volume: 9 Issue: 3
Author(s): Howard H.W. Chan, Anthony K.C. Chan, Iakovina Alexopoulou and Keith K. Lau
Affiliation:
Keywords: Thrombotic thrombocytopenic purpura, hemolytic uremic syndrome, TTP, HUS.
Abstract: Thrombotic thrombocytopenic purpura (TTP) is a rare pediatric disease, yet has grave outcome if not managed properly. It shares many common clinical features with hemolytic uremic syndrome (HUS). While it is still disputable whether TTP and HUS are clinically related disorders, recent studies indicate that severe deficiency of a von Willebrand factor (vWF) cleaving protease is one of the primary causes of TTP. In this discussion, we will focus on TTP in reference to the deficiency of this protease, with the objective of increasing awareness among pediatric healthcare professionals of this less commonly recognized disease.
Export Options
About this article
Cite this article as:
H.W. Chan Howard, K.C. Chan Anthony, Alexopoulou Iakovina and K. Lau Keith, Thrombotic Thrombocytopenic Purpura, from the Perspectives of a Pediatrician, Current Pediatric Reviews 2013; 9 (3) . https://dx.doi.org/10.2174/1573396311309030005
DOI https://dx.doi.org/10.2174/1573396311309030005 |
Print ISSN 1573-3963 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6336 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Use of Benzodiazepines and Haloperidol Among Orthopedic Patients in Postoperative Delirium. A Systematic Review
Current Psychopharmacology The Use of Biomarkers for Assessing HAART-Associated Renal Toxicity in HIV-Infected Patients
Current HIV Research Utilization of Evidence-Based Secondary Prevention Medications at the Time of Discharge in Patients with Acute Coronary Syndrome (ACS) in Qatar
Current Vascular Pharmacology Editorial [Hot Topic: Sepsis (Guest Editor: David E. Joyce)]
Current Drug Targets Distribution, Bioactivities and Therapeutical Potentials of Pentagalloylglucopyranose
Current Bioactive Compounds Difference in Blood Pressure Measurements Between Arms: Methodological and Clinical Implications
Current Pharmaceutical Design Systemic Hypertension in Patients with Aortic Stenosis: Clinical Implications and Principles of Pharmacological Therapy
Cardiovascular & Hematological Agents in Medicinal Chemistry Review of Vital Signs Monitoring Systems – Patient’s Acceptability, Issues and Challenges
Neuroscience and Biomedical Engineering (Discontinued) Parkinson’s Disease: Recent Updates in the Identification of Human Dopa Decarboxylase Inhibitors
Current Drug Metabolism CD44 and its Role in Inflammation and Inflammatory Diseases
Inflammation & Allergy - Drug Targets (Discontinued) Hydroxyimine NO-Donors; FK409 and Derivatives
Current Topics in Medicinal Chemistry Organic Lesions in the Brain MRI of Children with Febrile Seizure
Current Medical Imaging Cardiovascular Considerations of Remdesivir and Favipiravir in the Treatment of COVID-19
Cardiovascular & Hematological Disorders-Drug Targets Cutaneous Neurovascular Interaction Involved in Tactile Sensation
Cardiovascular & Hematological Agents in Medicinal Chemistry Targeting the Noradrenergic System in Posttraumatic Stress Disorder: A Systematic Review and Meta-Analysis of Prazosin Trials
Current Drug Targets Prevention of Atherosclerosis by Interference with the Vascular Nitric Oxide System
Current Pharmaceutical Design Genesis of Dihydropyrimidinone Calcium Channel Blockers: Recent Progress in Structure-Activity Relationships and Other Effects
Mini-Reviews in Medicinal Chemistry The Beneficial Effects of Sulfur-containing Amino Acids on Cisplatininduced Cardiotoxicity and Neurotoxicity in Rodents
Current Medicinal Chemistry Anticancer Potential of Thiazole Derivatives: A Retrospective Review
Mini-Reviews in Medicinal Chemistry Hypersensitivity Reactions to Neuromuscular Blocking Agents
Current Pharmaceutical Design