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Letters in Organic Chemistry


ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

PEG Encapsulation of Porphyrins for Cell Imaging and Photodynamic Therapy

Author(s): Jinjun Liu, Licui Zhang, Xiaojuan Du, Fengxia Cui, Chunlei Du and Baoxiang Gao

Volume 10, Issue 5, 2013

Page: [342 - 347] Pages: 6

DOI: 10.2174/1570178611310050007

Price: $65


Polyethylene glycol (PEG) encapsulation of porphyrin was designed and synthesized by introducing branched PEG substituents to the porphyrin core. Fluorescence imaging of cells was conducted to investigate the cellular uptake of these PEPPs. Results suggest that the porphyrin compound with 16 triethylene glycol chains exhibits increased cellular uptake and/or efficiency for emitting fluorescence inside the cells. The singlet oxygen yield of the porphyrin compound with 16 triethylene glycol chains is determined to be 0.93. This high singlet oxygen yield may be attributed to the large number of polyethylene glycol chains that hinder aggregation and excited-state quenching. PEPPs exhibit potential as a new class of photosensitizers for photodynamic therapy because of their water solubility, good biocompatibility, and high singlet oxygen yield.

Keywords: Porphyrins, photosensitizers, singlet oxygen yields, fluorescence imaging.

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