Abstract
A highly enantioselectiveorganocatalyticnitromethylphenylsulfone addition to aliphatic α,β-unsaturated aldehydes is reported. The reaction is catalyzed by simple and commercially available secondary amines, affording the cyclic compounds in moderate yields, good diastereoselectivities and excellent enantioselectivities.
Keywords: Cascade reaction, enantioselective, organocatalysis, asymmetric synthesis, secondary amine, cyclization.
Current Organic Synthesis
Title:First Enantioselective Organocatalytic Addition of Nitromethylphenylsulfone to Enals. Enantioselective Synthesis of Cyclohexenones Bearing 3 Contiguousstereogeniccenters
Volume: 10 Issue: 3
Author(s): Ramon Rios, SimonaHybelbauerova, Ivana Csarova and Jan Vesely
Affiliation:
Keywords: Cascade reaction, enantioselective, organocatalysis, asymmetric synthesis, secondary amine, cyclization.
Abstract: A highly enantioselectiveorganocatalyticnitromethylphenylsulfone addition to aliphatic α,β-unsaturated aldehydes is reported. The reaction is catalyzed by simple and commercially available secondary amines, affording the cyclic compounds in moderate yields, good diastereoselectivities and excellent enantioselectivities.
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Cite this article as:
Rios Ramon, SimonaHybelbauerova , Csarova Ivana and Vesely Jan, First Enantioselective Organocatalytic Addition of Nitromethylphenylsulfone to Enals. Enantioselective Synthesis of Cyclohexenones Bearing 3 Contiguousstereogeniccenters, Current Organic Synthesis 2013; 10 (3) . https://dx.doi.org/10.2174/1570179411310030008
DOI https://dx.doi.org/10.2174/1570179411310030008 |
Print ISSN 1570-1794 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6271 |
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