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Combinatorial Chemistry & High Throughput Screening

Editor-in-Chief

ISSN (Print): 1386-2073
ISSN (Online): 1875-5402

Cu(II) Schiff Base Complex as a Highly Efficient Catalyst for the Synthesis of Polyhydroquinoline Derivatives via Hantzsch Condensation in Water

Author(s): Seyed Mohammad Vahdat

Volume 16 , Issue 10 , 2013

Page: [782 - 787] Pages: 6

DOI: 10.2174/13862073113169990003

Price: $65

Abstract

In the present study, Cu(II) Schiff-base complex is introduced as a highly efficient and green solid catalyst for the unsymmetrical Hantzsch condensation through a four-component coupling of various aldehydes, dimedone, ethyl acetoacetate and ammonium acetate to form polyhydroquinoline derivatives in good to excellent yields. This reaction was carried out in the presence of 1 mol% of catalysts in water at room temperature. The reusability of the catalysts was demonstrated by a five-run test. Remarkable features of this new procedure are cleaner reaction profiles, shorter reactiontimes, simple experimental and work-up procedures.

Keywords: Cu(II) schiff-base catalyst, hantzsch condensation, polyhydroquinoline, water solvent.


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