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Anti-Cancer Agents in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1871-5206
ISSN (Online): 1875-5992

The Application of Fungal Beta-glucans for the Treatment of Colon Cancer

Author(s): Jiezhong Chen, Xu Dong Zhang and Zhengyi Jiang

Volume 13 , Issue 5 , 2013

Page: [725 - 730] Pages: 6

DOI: 10.2174/1871520611313050007

Price: $65

Abstract

Mushrooms have been consumed for their health benefits for thousands of years in China, and the main active component was recently identified as beta-glucan. The immune-stimulating effect of beta-glucans has been well studied, and several beta-glucan receptors have been identified on the surface of immune cells. In addition, mushroom extracts with high levels of beta-glucans have also been shown to have direct cytotoxic effects on cancer cells, and beta-glucans are used for the treatment of cancer. This review summarizes the use of beta-glucans in colon cancer. Evidence has supported the idea that beta-glucans can decrease the size of xenografted colon cancer tumors via the stimulation of the immune system and direct cytotoxicity. Beta-glucans can also have synergistic effects with chemotherapeutic agents and other immune stimulators, and an innovative strategy is to use beta-glucans to deliver nanoparticles containing chemotherapeutic agents to the site of the colon cancer and, thus, improve the therapeutic efficacy.

Keywords: Beta-glucans, macrophages, dendritic cells, cytotoxicity, nanoparticles.


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