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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Bioavailability of Quercetin: Problems and Promises

Author(s): X. Cai, Z. Fang, J. Dou, A. Yu and G. Zhai

Volume 20 , Issue 20 , 2013

Page: [2572 - 2582] Pages: 11

DOI: 10.2174/09298673113209990120


Quercetin (QC) is a typical plant flavonoid, possesses diverse pharmacologic effects including antiinflammatory, antioxidant, anti-cancer, anti-anaphylaxis effects and against aging. However, the application of QC in pharmaceutical field is limited due to its poor solubility, low bioavailability, poor permeability and instability. To improve the bioavailability of QC, numerous approaches have been undertaken, involving the use of promising drug delivery systems such as inclusion complexes, liposomes, nanoparticles or micelles, which appear to provide higher solubility and bioavailability. Enhanced bioavailability of QC in the near future is likely to bring this product to the forefront of therapeutic agents for treatment of human disease.

Keywords: Bioavilability, formulations, inclusion complexes, liposomes, micelles, nanoparticles, prodrug, quercetin, solubility.

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