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Letters in Drug Design & Discovery

Editor-in-Chief

ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Inhibitory Effects of Substituted Cinnamic Acid Esters on Mushroom Tyrosinase

Author(s): Zhenghua Zhang, Jinbing Liu, Fengyan Wu and Liangzhong Zhao

Volume 10 , Issue 6 , 2013

Page: [529 - 534] Pages: 6

DOI: 10.2174/1570180811310060009

Price: $65

Abstract

A series of substituted cinnamic acid esters were synthesized and their inhibitory effects on the diphenolase activity of mushroom tyrosinase were evaluated. Compound 8 was found to be the most potent inhibitor with IC50 value of 5.60µM. Preliminary structure activity relationships (SARs) were concluded. The inhibition kinetics analyzed by Lineweaver–Burk plots revealed that compound 8 was anti-competitive inhibitor.

Keywords: Substituted cinnamic acid esters, Tyrosinase inhibitor, Synthesis, Structure activity relationships, Inhibition kinetics, Anti-competitive inhibitor.


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