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Letters in Drug Design & Discovery


ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Diversity in Antibacterial Activity of Thiosemicarbazides Derived from 3-Chlorobenzhydrazide

Author(s): Tomasz Plech, Monika Wujec, Urszula Kosikowska and Anna Malm

Volume 10 , Issue 6 , 2013

Page: [492 - 496] Pages: 5

DOI: 10.2174/1570180811310060004

Price: $65


3-Chlorobenzoic acid hydrazide was reacted with different aryl isothiocyanates to give the corresponding 1-(3- chlorobenzoyl)-4-substituted thiosemicarbazides 1-16. Reaction yields ranged from 74 to 96%. Structures of the synthesized compounds were defined on the basis of 1H NMR and IR spectra. As it was showed the antibacterial activity of the obtained compounds was limited only towards Gram-positive bacteria. As regards B. cereus ATCC 10876, 1-(3- chlorobenzoyl)-4-(3,5-dichlorophenyl)thiosemicarbazide (8) was 16 times more active than ampicillin and 8 times more active than cefuroxime.

Keywords: Hydrazides, Structure-activity relationships, MIC, MRSA.

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