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Current Drug Targets


ISSN (Print): 1389-4501
ISSN (Online): 1873-5592

Basic Mechanisms of Augmentation of Antidepressant Effects with Thyroid Hormone

Author(s): Tsuri Lifschytz, Ronen Segman, Galit Shalom, Bernard Lerer, Eitan Gur, Tanya Golzer and Michael E. Newman

Volume 7, Issue 2, 2006

Page: [203 - 210] Pages: 8

DOI: 10.2174/138945006775515482

Price: $65


The thyroid hormone triiodothyronine (T3) has been used both to augment and accelerate the clinical effects of antidepressants, particularly the tricyclics. More recent work indicates that it may have similar actions with regard to the SSRIs. Two main mechanisms have been put forward to explain its antidepressant actions, (a) an action at the nuclear level involving stimulation of gene transcription, (b) an action at the cell membrane level involving potentiation of neurotransmission. In particular, there is considerable evidence for potentiation by T3 of the actions of the neurotransmitter 5- HT or serotonin. This evidence, which is mainly based on in vivo microdialysis studies, is reviewed, and evidence based on human and animal neuroendocrine studies considered. The effects of T3, alone and together with the SSRI fluoxetine, on mRNA levels for the 5-HT1A and 5-HT1B autoreceptors, which mediate serotonergic neurotransmission by feedback actions at the levels of cell firing(somatodendritic 5-HT1A autoreceptors) and neurotransmitter release (nerve terminal 5- HT1B autoreceptors) were also determined. Administration of a combination of fluoxetine and T3 induced reductions in the transcription of these autoreceptors, which may explain the clinical potentiating effects of this combination, and thus link the nuclear and neurotransmitter hypotheses of T3 action.

Keywords: Triiodothyronine, serotonin, depression, antidepressant, microdiaysis, mRNA, fluoxetine, autoreceptor

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