Abstract
In this review we have summarized the known virulent factors of P. aeruginosa in the development of ventilator associated pneumonia (VAP). This gram negative rod bacterium colonizes through several pathogenic mechanisms that can be summarized as follows: 1) cell surface virulence factors; 2) secreted virulence factors; 3) type secretion system; 4) quorum sensing. Another additional aspect that is covered is the capacity of P. aeruginosa of organized growth as a biofilm, which is a particular growth pattern in which bacteria gain high levels of antimicrobial resistance. The development of new antimicrobial strategies may use this understanding of the bacterium behavior for possible prevention, or eradication of the infective agent, in case of severe infections.
Keywords: Biofilm, Pseudomonas aeruginosa, quorum sensing, type III secretion system, ventilator-associated pneumonia (VAP), virulence factors.
Current Respiratory Medicine Reviews
Title:Recent Findings Regarding Pathogenesis and Prevention of Ventilator- Associated Pneumonia
Volume: 9 Issue: 1
Author(s): Michele Introna, Riccardo Pinciroli, Edward A. Bittner and Lorenzo Berra
Affiliation:
Keywords: Biofilm, Pseudomonas aeruginosa, quorum sensing, type III secretion system, ventilator-associated pneumonia (VAP), virulence factors.
Abstract: In this review we have summarized the known virulent factors of P. aeruginosa in the development of ventilator associated pneumonia (VAP). This gram negative rod bacterium colonizes through several pathogenic mechanisms that can be summarized as follows: 1) cell surface virulence factors; 2) secreted virulence factors; 3) type secretion system; 4) quorum sensing. Another additional aspect that is covered is the capacity of P. aeruginosa of organized growth as a biofilm, which is a particular growth pattern in which bacteria gain high levels of antimicrobial resistance. The development of new antimicrobial strategies may use this understanding of the bacterium behavior for possible prevention, or eradication of the infective agent, in case of severe infections.
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Introna Michele, Pinciroli Riccardo, Bittner Edward A. and Berra Lorenzo, Recent Findings Regarding Pathogenesis and Prevention of Ventilator- Associated Pneumonia, Current Respiratory Medicine Reviews 2013; 9 (1) . https://dx.doi.org/10.2174/1573398X11309010004
DOI https://dx.doi.org/10.2174/1573398X11309010004 |
Print ISSN 1573-398X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6387 |
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