Generic placeholder image

Current Pharmaceutical Design


ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

New Insights into Invasive Aspergillosis - from the Pathogen to the Disease

Author(s): Ulrike Binder and Cornelia Lass-Florl

Volume 19, Issue 20, 2013

Page: [3679 - 3688] Pages: 10

DOI: 10.2174/13816128113199990366

Price: $65


Disease manifestations with Aspergillus spp. are very diverse and dependent on interaction between the fungus and the host. Invasive aspergillosis (IA) is the most severe form of Aspergillus - associated disease found in immunocompromised hosts. Infections are mainly due to Aspergillus (A.) fumigatus, an air-borne opportunistic pathogen that causes 90% of IA. Mortality rate of this disease is still very high (50-95%), partly because of diagnostic difficulties, limited antifungal treatment options, weak conditions of patients at risk; but also in part because understanding of virulence factors involved in A. fumigatus pathogenicity and interactions of the pathogen with the host immune system is still poor. This review focuses on properties of A. fumigatus in terms of putative virulence factors and interactions of the pathogen with a main focus on the innate immune system.

Keywords: Invasive aspergillosis, virulence, pathogenicity factors, classification of IA, innate immune response.

Rights & Permissions Print Export Cite as
© 2023 Bentham Science Publishers | Privacy Policy