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Current Nanoscience


ISSN (Print): 1573-4137
ISSN (Online): 1875-6786

Highly Resolution of Propranolol Using Oxidized Multi-walled Carbon Nanotubes and β-cyclodextrin Derivatives as Impregnating Reagents

Author(s): Xiao-Qing Chen, Cong-Hao Sun, Fei-Peng Jiao, Jin-Gang Yu and Xin-Yu Jiang

Volume 9, Issue 2, 2013

Page: [221 - 224] Pages: 4

DOI: 10.2174/1573413711309020009

Price: $65


By using oxidized multi-walled carbon nanotubes and β-cyclodextrin derivatives (methyl-β-cyclodextrin or hydroxypropyl-β- cyclodextrin) as impregnating reagents, high efficiently resolution of (±)-propranolol, a kind of commonly used β-blockers, has been achieved on abovementioned reagents impregnated silica gel GF254 layers. The solvent system tert-butanol-acetonitrile with various volume ratios was further investigated. By detecting the spots at 254 nm with a UV lamp, the obtained chiral separation factors indicated oxidized multi-walled carbon nanotubes and β-cyclodextrin derivatives impregnated TLC plates could be used for effectively chiral recognition of racemic compounds.

Keywords: Methyl-β-cyclodextrin, hydroxypropyl-β-cyclodextrin, oxidized multi-walled carbon nanotubes, thin-layer chromatography, resolution.

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