Nitrogen Containing Privileged Structures and their Solid Phase Combinatorial Synthesis

Title:Nitrogen Containing Privileged Structures and their Solid Phase Combinatorial Synthesis

Volume: 16 Issue: 5

Author(s): Amit Verma, Mange Ram Yadav, Rajani Giridhar, Navnit Prajapati, Avinash C. Tripathi and Shailendra K. Saraf

Affiliation:

Keywords: Benzodiazepine, combinatorial synthesis, cyclic peptides, nitrogen heterocyclics, privileged structures, purines and pyrimidines, solid-phase synthesis.

Abstract: The existence of preferred molecular scaffolds that possess inherent biological activity, called privileged structures, is now well recognized. Such privileged structures not only provide enhanced drug-like properties but also give new hits for developing leads. The synthesis of combinatorial libraries, especially with the insertion of privileged substructures into heterocyclic moieties containing nitrogen, provides for a greater probability of the discovery of novel lead compounds using chemical transformation. The review focuses on the progress in the solid-phase synthetic strategies of nitrogen containing privileged structures over the years.

Cite this article as:

Verma Amit, Yadav Ram Mange, Giridhar Rajani, Prajapati Navnit, Tripathi C. Avinash and Saraf K. Shailendra, Nitrogen Containing Privileged Structures and their Solid Phase Combinatorial Synthesis, Combinatorial Chemistry & High Throughput Screening 2013; 16 (5) . https://dx.doi.org/10.2174/1386207311316050003