Lipoxygenase: An Emerging Target for Stroke Therapy

Klaus van      Leyen

Abstract

Neuroprotection as approach to stroke therapy has recently seen a revival of sorts, fueled in part by the continuing necessity to improve acute stroke care, and in part by the identification of novel drug targets. 12/15- Lipoxygenase (12/15-LOX), one of the key enzymes of the arachidonic acid cascade, contributes to both neuronal cell death and vascular injury. Inhibition of 12/15-LOX may thus provide multifactorial protection against ischemic injury. Targeting 12/15-LOX and related eicosanoid pathways is the subject of this brief review.

Keywords: Ischemic stroke, neuroprotection, oxidative stress, eicosanoid, lipoxygenase, arachidonic acid cascade.

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