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Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

A New Application of Mohr’s Salt as a Cheap and Powerful Catalyst for Synthesis of Novel Pyranocoumarins

Author(s): Bahador Karami, Saeed Khodabakhshi and Khalil Eskandari

Volume 10, Issue 2, 2013

Page: [105 - 110] Pages: 6

DOI: 10.2174/1570178611310020007

Price: $65

Abstract

A new application of Mohr's salt (ammonium iron (II) sulfate hexahydrate) has been found in an organic reaction in which the Knoevenagel condensation, Michael addition, and intermolecular cyclization of 4-hydroxyxoumarin, malononitrile and aromatic aldehydes led to novel and known pyranocoumarins. Simple operation, use of readily accessible commercial starting materials, good to excellent yields and short reaction times show efficiency of this method for the synthesis of these biologically interesting products.

Keywords: Mohr's salt, 4-hydroxycoumarin, pyranocoumarin, knoevenagel, michael


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