Abstract
In addition to their participation in metabolic processes and control of programmed cell death, the role of mitochondria as a fundamental hub for innate anti-viral immunity is now emerging. The participation of the mitochondrial antiviral signaling protein (MAVS) as a central regulator of a complex signaling cascade, which results in the induction of antiviral and inflammatory responses has been described. A patent based on this role of MAVS is highlighted in this review.
Keywords: Immunity, MAVS, mitochondria, viral infection
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery
Title:MAVS: A New Weapon in the Fight Against Viral Infections
Volume: 7 Issue: 2
Author(s): Jose A. Boga, Maria de Ona, Santiago Melon, Marta E. Alvarez-Arguelles, Ana Morilla and Ana Coto-Montes
Affiliation:
- Servicio de Microbiologia, Hospital Universitario Central de Asturias, Calle Celestino Villamil s/n, 33006-Oviedo, Spain.,Spain
Keywords: Immunity, MAVS, mitochondria, viral infection
Abstract: In addition to their participation in metabolic processes and control of programmed cell death, the role of mitochondria as a fundamental hub for innate anti-viral immunity is now emerging. The participation of the mitochondrial antiviral signaling protein (MAVS) as a central regulator of a complex signaling cascade, which results in the induction of antiviral and inflammatory responses has been described. A patent based on this role of MAVS is highlighted in this review.
Export Options
About this article
Cite this article as:
A. Boga Jose, de Ona Maria, Melon Santiago, E. Alvarez-Arguelles Marta, Morilla Ana and Coto-Montes Ana, MAVS: A New Weapon in the Fight Against Viral Infections, Recent Patents on Endocrine, Metabolic & Immune Drug Discovery 2013; 7(2) . https://dx.doi.org/10.2174/1872214811307020004
DOI https://dx.doi.org/10.2174/1872214811307020004 |
Print ISSN 1872-2148 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3334 |
Related Articles
-
Recent Developments of Rebeccamycin Analogues as Topoisomerase I Inhibitors and Antitumor Agents.
Current Medicinal Chemistry The Pim Kinases: New Targets for Drug Development
Current Drug Targets Hereditary Papillary Renal Carcinoma Type I
Current Molecular Medicine Biology of Protooncogene c-kit Receptor and Spermatogenesis
Current Pharmacogenomics Delta Np63 alpha – Responsive microRNA Modulate the Expression of Metabolic Enzymes
Current Pharmaceutical Biotechnology Effect of Recombinant Human Thymosin-α1, an Immuno-Modulating Peptide with 28 Amino Acids, on the Activity of Cytochrome P450s
Drug Metabolism Letters Molecular Treatment of Different Breast Cancers
Anti-Cancer Agents in Medicinal Chemistry Highly Organized Nanostructures for Brain Drug Delivery - New Hope or Just a Fad?
CNS & Neurological Disorders - Drug Targets Nanoparticulate Iron Oxide Contrast Agents for Untargeted and Targeted Cardiovascular Magnetic Resonance Imaging
Current Nanoscience Miracles of Herbal Phytomedicines in Treatment of Skin Disorders: Natural Healthcare Perspective
Infectious Disorders - Drug Targets Absorption, Pharmacokinetics and Disposition of Biodegradable Nanoscale Preparations
Current Drug Metabolism A Review of Coumarin Derivatives in Pharmacotherapy of Breast Cancer
Current Medicinal Chemistry Molecular Pharmacology of Malignant Pleural Mesothelioma: Challenges and Perspectives From Preclinical and Clinical Studies
Current Drug Targets A Knock-Down Cell-Based Study for the Functional Analysis of Chloride Intracellular Channel 1 (CLIC1): Integrated Proteomics and Microarray Study
Protein & Peptide Letters Xanthone Derivatives: New Insights in Biological Activities
Current Medicinal Chemistry The Effect of A Hexanoic Acid Linker Insertion on the Pharmacokinetics and Tumor Targeting Properties of the Melanoma Imaging Agent 99mTc-HYNIC-cycMSH
Anti-Cancer Agents in Medicinal Chemistry Effect of Electromagnetic Radiations on Neurodegenerative Diseases- Technological Revolution as a Curse in Disguise
CNS & Neurological Disorders - Drug Targets The Regulation of FoxP3-Expressing Regulatory T Cells
Endocrine, Metabolic & Immune Disorders - Drug Targets Hypoxia Signaling and the Metastatic Phenotype
Current Molecular Medicine The Cold Case of Metabotropic Glutamate Receptor 6: Unjust Detention in the Retina?
Current Neuropharmacology