Abstract
siRNA-induced RNA Interference (RNAi) responses have great potential to treat human disease; however, siRNAs are highly charged macromolecules with no ability to enter cells and require a delivery agent. Peptide Transduction Domains (PTDs), also called Cell Penetrating Peptides (CPPs), are delivery peptides with the potential to deliver macromolecular peptides, proteins and siRNAs into cells. Here we discuss the multitude of ways that PTDs/CPPs have been utilized to deliver siRNAs from direct conjugates to complex nanoparticles. PTD/CPP-mediated siRNA delivery has come a long way and has great potential to address the siRNA delivery problem.
Keywords: PTD, CPP, siRNA, RNAi, nanoparticles, cell deliverY, macropinocytosis
Current Pharmaceutical Design
Title:PTD/CPP Peptide-Mediated Delivery of siRNAs
Volume: 19 Issue: 16
Author(s): Asaf Presente and Steven F. Dowdy
Affiliation:
Keywords: PTD, CPP, siRNA, RNAi, nanoparticles, cell deliverY, macropinocytosis
Abstract: siRNA-induced RNA Interference (RNAi) responses have great potential to treat human disease; however, siRNAs are highly charged macromolecules with no ability to enter cells and require a delivery agent. Peptide Transduction Domains (PTDs), also called Cell Penetrating Peptides (CPPs), are delivery peptides with the potential to deliver macromolecular peptides, proteins and siRNAs into cells. Here we discuss the multitude of ways that PTDs/CPPs have been utilized to deliver siRNAs from direct conjugates to complex nanoparticles. PTD/CPP-mediated siRNA delivery has come a long way and has great potential to address the siRNA delivery problem.
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Cite this article as:
Presente Asaf and F. Dowdy Steven, PTD/CPP Peptide-Mediated Delivery of siRNAs, Current Pharmaceutical Design 2013; 19 (16) . https://dx.doi.org/10.2174/1381612811319160008
DOI https://dx.doi.org/10.2174/1381612811319160008 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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