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Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

5-Lipoxygenase, Leukotrienes Biosynthesis and Potential Antileukotrienic Agents

Author(s): Josef Jampilek, Martin Dolezal, Veronika Opletalova and Jiri Hartl

Volume 13 , Issue 2 , 2006

Page: [117 - 129] Pages: 13

DOI: 10.2174/092986706775197935

Price: $65

Abstract

Leukotrienes play an important role in the inflammatory process accompanying allergic diseases of respiratory, gastrointestinal and dermatological systems. Leukotrienes are generated from arachidonic acid as a result of the 5-lipoxygenase action. This paper deals with 5-lipoxygenase action mechanism and the following biosynthesis of all leukotrienes. In this article, potential antileukotrienic agents are classified according to their mechanism of action. The original antileukotrienic compounds of the Research Institute for Pharmacy and Biochemistry in Prague (VUFB), Czech Republic are presented in a separate chapter of the paper.

Keywords: 5-lipoxygenase, FLAP, LTA4-hydrolase, leukotrienes, antileukotrienic agents

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